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This study identifies a unique population of regulatory T cells in the murine meninges that play a crucial role in maintaining brain homeostasis by regulating local immune responses. These Treg cells prevent the infiltration of interferon-γ-producing lymphocytes into the brain, thereby protecting neural stem cells and supporting neurogenesis in the hippocampus. The findings highlight the importance of meningeal Treg cells in safeguarding cognitive functions and suggest their potential as therapeutic targets

Author

Renato Rojas Dominguez

Language

EN