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Corticotropin releasing factor in the nucleus basalis of Meynert impairs attentional performance and reduces levels of glutamate and taurine in male and female rats by Samantha R. Eck; Nikolaos Kokras; Brittany Wicks; Petros Baltimas; Arron Hall; Nina van Bendegem; Madeleine Salvatore; Sarah R. Cohen; Joy Bergmann; Attilio Ceretti; Vinay Parikh; Christina Dalla; Debra A. Bangasser is a Neuroscience article available to read on EtoBox.

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Psychiatric disorders that are characterized by impairments in sustained attention, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), and major depression are also sensitive to exacerbation by stress. Sustained attention relies on cholinergic and non-cholinergic projections from the nucleus basalis of Meynert (NBM) in the basal forebrain to the medial prefrontal cortex (mPFC). We have previously shown that central administration of the stress neuropeptide corticotropin releasing factor (CRF) impairs performance on the sustained attention task (SAT) in adult male and female rats. The present study investigated whether this effect was mediated by CRF's action in the NBM. Rats were administered CRF in the NBM and subsequent SAT performance was measured. A high dose of CRF (100 ng) significantly impaired performance on non-signaled events across sex. Because performance on non-signaled events is believed to depend on non-cholinergic (i.e., GABA and glutamate) signaling, high performance liquid chromatography was used to quantify amino acid levels in the NBM and mPFC. We found females have higher levels of glutamate, glutamine, GABA glycin

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Author

Samantha R. Eck; Nikolaos Kokras; Brittany Wicks; Petros Baltimas; Arron Hall; Nina van Bendegem; Madeleine Salvatore; Sarah R. Cohen; Joy Bergmann; Attilio Ceretti; Vinay Parikh; Christina Dalla; Debra A. Bangasser

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)