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What is Mouse Genetic Variation in Disease Modeling about?

This document discusses using genetic variation in mice to model human disease and biology. It proposes using traditional genetic techniques like recombinant inbred strains as well as new collaborative cross (CC) mouse populations, which capture genetic variation similarly to human populations. The CC allows for high-powered genome-wide association studies across many mouse strains and replicates, helping to map genes related to traits and diseases. Phenotypic studies of inbred mouse strains can also help i

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