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Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke by Dan Lu; Eric S. Ho; Hongcheng Mai; Jiankun Zang; Yanfang Liu; Yufeng Li; Bing Yang; Yan Ding; Chi Kwan Tsang; Anding Xu is a Neuroscience article available to read on EtoBox.
What is Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke about?
Many hospitals lack facilities for accurate diagnosis of acute ischemic stroke (AIS). Circular RNA (circRNA) is highly expressed in the brain and is closely associated with stroke. In this study, we examined whether the blood-borne circRNAs could be promising candidates as adjunctive diagnostic biomarkers and their pathophysiological roles after stroke. We profiled the blood circRNA expression in mice subjected to experimental focal cerebral ischemia and validated the selected circRNAs in AIS patients. We demonstrated that 128, 198, and 789 circRNAs were significantly altered at 5 min, 3 h, and 24 h after ischemic stroke, respectively. Our bioinformatics analysis revealed that the circRNA-targeted genes were associated with the Hippo signaling pathway, extracellular matrix-receptor interaction, and fatty acid metabolism at 5 min, 3 h and 24 h after ischemic stroke, respectively. We verified that many of these circRNAs existed in the mouse brain. Furthermore, we found that most of the predicted circRNA-miRNA interactions apparently exhibited functional roles in terms of regulation of their target gene expression in the brain. We also verified that many of these mouse circRNAs were c
Who reads Identification of Blood Circular RNAs as Potential Biomarkers for Acute Ischemic Stroke?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dan Lu; Eric S. Ho; Hongcheng Mai; Jiankun Zang; Yanfang Liu; Yufeng Li; Bing Yang; Yan Ding; Chi Kwan Tsang; Anding Xu
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2007- (ISSN 1662-4548)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)