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Can I read Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal. on EtoBox?
Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal. by Spoorti Kulkarni; Harishanker Alampally; Vasudev Guddattu; Gabriel Rodrigues; Sunitha Carnelio is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal. about?
Background: Various stemness markers (SOX2, OCT4, and NANOG) have been studied in odontogenic cysts and tumors. However, studies on SALL4 having similar properties of stemness has not been documented. Additionally, insight into fascin as a migratory molecule is less explored. Following a thorough literature search we hypothesize that fascin might contribute for the local migratory behaviour of the odontogenic epithelial cells in tumors and cysts while SALL4 may contribute to stemness property. Thus, the aim of the present study was to evaluate the expression of fascin and SALL4 in histopathological variants of Ameloblastoma, Adenomatoid Odontogenic Tumor (AOT) and various odontogenic cysts namely Odontogenic keratocyst (OKC), Dentigerous cyst (DC), Radicular cyst (RC), and Calcifying odontogenic cyst (COC). Methods: Semi-quantitative analysis of fascin and SALL4 immuno-positive cells was evaluated in a total of 40 cases of ameloblastoma (11 plexiform, 12 follicular, 12 unicystic, and 5 desmoplastic) variants, 6 cases of AOT, 15 cases each of OKC, DC, RC and 5 of COC. Chi-square test was applied to evaluate the association between SALL4 and fascin expression in odontogenic cysts an
Who reads Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Spoorti Kulkarni; Harishanker Alampally; Vasudev Guddattu; Gabriel Rodrigues; Sunitha Carnelio
- Publisher
- F1000 Research Ltd
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)