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Can I read Lovastatin modulation of microglial activation via suppression of functional CD40 expression on EtoBox?
Lovastatin modulation of microglial activation via suppression of functional CD40 expression by Kirk P. Townsend; Doug R. Shytle; Yun Bai; Nan San; Jin Zeng; Melissa Freeman; Takashi Mori; Francisco Fernandez; David Morgan; Paul Sanberg; Jun Tan is a Neuroscience article available to read on EtoBox.
What is Lovastatin modulation of microglial activation via suppression of functional CD40 expression about?
## Abstract Recent studies have shown that the 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) possess antiinflammatory and immunomodulatory properties, distinct from their action of lowering serum lipid levels. Moreover, results of epidemiological studies suggest that long‐term use of statins is associated with a decreased risk for Alzheimer's disease (AD). Interestingly, lovastatin (one of the most commonly used anticholesterol drugs) treatment of vascular‐derived cells has been reported to antagonize activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, and it is well known that the JAK/STAT pathway plays a central role in interferon‐γ (IFN‐γ)‐induced microglial CD40 expression. We and others have previously reported that microglial CD40 expression is significantly induced by IFN‐γ and amyloid‐β (Aβ) peptide. Moreover, it has been shown that CD40 signaling is critically involved in microglia‐related immune responses in the CNS. In this study, we examined the putative role of lovastatin in modulation of CD40 expression and its signaling in cultured microglia. RT‐PCR, Western immunoblotting, and flow cy
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- Author
- Kirk P. Townsend; Doug R. Shytle; Yun Bai; Nan San; Jin Zeng; Melissa Freeman; Takashi Mori; Francisco Fernandez; David Morgan; Paul Sanberg; Jun Tan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)