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Anticancer Natural Products Targeting Immune Checkpoint Protein Network by Kyung-Soo Chun; Do-Hee Kim; Pawan Kumar Raut; Young-Joon Surh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Anticancer Natural Products Targeting Immune Checkpoint Protein Network about?

Normal cells express surface proteins that bind to immune checkpoint proteins on immune cells to turn them off, whereby the immune system does not attack normal healthy cells. Cancer cells can also utilize this same protective mechanism by expressing surface proteins that can interact with checkpoint proteins on immune cells to overcome the immune surveillance. Immunotherapy is making the best use of the body's own immune system to reinforce anti-tumor responses. The most generally used immunotherapy is the control of immune checkpoints including the cytotoxic T lymphocyte-associated molecule 4 (CTLA-4), programmed cell deathreceptor 1 (PD-1), or programmed cell death ligand-1 (PD-L1). In spite of the clinical effectiveness of immune checkpoint inhibitors, the overall response rate still remains low. Therefore, there have been considerable efforts in searching for alternative immune checkpoint proteins that may work as new therapeutic targets for treatment of cancer. Recent studies have identified several additional novel immune checkpoint targets, including lymphocyte activation gene-3, T cell immunoglobulin and mucin-domain containing-3, T cell immunoglobulin and immunoreceptor t

Who reads Anticancer Natural Products Targeting Immune Checkpoint Protein Network?

Author

Kyung-Soo Chun; Do-Hee Kim; Pawan Kumar Raut; Young-Joon Surh

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)