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Aspirin Reduces Platelet Aggregation During High-energy Excimer Laser by Ruiping Huang; Roshan B. Patel; Hongbao Ma; Kevin Taylor; George S. Abela is a Medicine article available to read on EtoBox.

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## Background and objectives: Excimer laser is used clinically in arterial revascularization procedures. this study evaluated the efficacy of aspirin in reducing platelet aggregation during high-energy excimer lasing. ## Study design/materials and methods: Platelet rich plasma (prp) from seven rabbits was circulated in a dual organ chamber with aspirin added to one and the other was control. prp was irradiated using an excimer laser (308 nm; 45 mj/mm(2); 25 hz; 5 minutes) via a 2.0 mm laser catheter. platelet aggregation (particle volume) was measured by laser-light scattering. morphology was evaluated by phase contrast and electron microscopy. ## Results: Baseline platelet volume was 3.4 microm(3) for both control and aspirin groups. following lasing, platelet volume peaked at 102.2 +/- 18.5 microm(3) for control compared to 43.1 +/- 49.2 microm(3) for aspirin-treated prp (p < 0.0001). ## Conclusion: Aspirin reduces large platelet aggregates but not small aggregates by 58% during lasing of prp.

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Author

Ruiping Huang; Roshan B. Patel; Hongbao Ma; Kevin Taylor; George S. Abela

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2006

Language

EN

Field

Medicine (Health Sciences)