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Abnormal immunoreactivity of the E‐cadherin/catenin (α‐, β‐, and γ‐) complex in premalignant and malignant non‐melanocytic skin tumours by Evangelia Papadavid; Massimo Pignatelli; Spyridon Zakynthinos; Thomas Krausz; Anthony C. Chu is a Medicine article available to read on EtoBox.

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## Abstract E‐cadherin/catenin (α‐, β‐, and γ‐) complex plays a critical role in the control of epithelial differentiation. The aim of this study was to examine the immunoreactivity of E‐cadherin and α‐, β‐, and γ‐catenins in premalignant and malignant non‐melanocytic skin tumours (NMST) and to correlate their expression with the grade of tumour differentiation, as assessed by the established histopathological criteria and by the Ki‐67 index. Benign NMSTs were also studied. To investigate any possible influence of immunosuppression in the expression of E‐cadherin and catenins, the study compared tumours obtained from renal transplant recipients (RTRs) and immunocompetent patients. Immunoperoxidase staining of E‐cadherin and α‐, β‐, and γ‐catenins was performed in 42 squamous cell carcinomas (SCCs) (26 from RTRs and 16 from non‐RTRs), 30 lesions of Bowen's disease (11 from RTRs and 19 from non‐RTRs), 11 atypical squamoproliferative lesions from RTRs, 19 actinic keratoses (9 from RTRs and 10 from non‐RTRs), and 20 viral warts from RTRs. The findings of this study were as follows. Firstly, the probability of abnormal expression of E‐cadherin and α‐, β‐, and γ‐catenins increased from b

Who reads Abnormal immunoreactivity of the E‐cadherin/catenin (α‐, β‐, and γ‐) complex in premalignant and malignant non‐melanocytic skin tumours?

Author

Evangelia Papadavid; Massimo Pignatelli; Spyridon Zakynthinos; Thomas Krausz; Anthony C. Chu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2001

Language

EN

Field

Medicine (Health Sciences)