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A composite hydrogel improves the survival and differentiation of human iPSC-derived neural stem cells after ischemic stroke by Yang Liu; Wen Zhang; Cheng Hu; Cheng Zheng; Fanjun Zhang; Li Yang; Zhengyong Li; Yunbing Wang is a Engineering article available to read on EtoBox.

What is A composite hydrogel improves the survival and differentiation of human iPSC-derived neural stem cells after ischemic stroke about?

Stem cell transplantation can replace lost and damaged neurons after ischemic stroke and has been proposed as a potential treatment for stroke. However, stem cell therapy is challenged by poor cell retention, survival, and differentiation following transplantation. In this study, we developed a composite hydrogel incorporating brain decellularized extracellular matrix (dECM) and a matrix metallopeptidase (MMP)-responsive host–guest (HG) hydrogel that acts as a platform for human induced pluripotent stem cell-derived neural stem cells (iPSC-NSCs) delivery to improve transplant stem cell survival and differentiation. The optimized composite hydrogel ratio was screened by rheology analysis and neurite outgrowth assessment. We then examined the effects of HG/dECM composite hydrogels on iPSC-NSCs survival and differentiation on two-dimensional surfaces modified with hydrogel and in a three-dimensional hydrogel network. Moreover, iPSC-NSCs-laden composite hydrogels were injected into the infarct cavity in an ischemic stroke model to replace lost and damaged nerve cells. As expected, the HG/dECM composite hydrogels better facilitated the survival and differentiation of iPSC-NSC in vivo th

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Author

Yang Liu; Wen Zhang; Cheng Hu; Cheng Zheng; Fanjun Zhang; Li Yang; Zhengyong Li; Yunbing Wang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)