Can I read Blood Levels Following Multiple Oral Dosing of Chlorpheniramine Conventional and Controlled Release Preparations on EtoBox?

Blood Levels Following Multiple Oral Dosing of Chlorpheniramine Conventional and Controlled Release Preparations by J. J. Vallner; J. A. Kotzan; J. T. Stewart; W. J. Brown; I. L. Honigberg; T. E. Needham; S. V. Dighe is a Medicine article available to read on EtoBox.

What is Blood Levels Following Multiple Oral Dosing of Chlorpheniramine Conventional and Controlled Release Preparations about?

## Abstract An examination of steady‐state performance of chlorpheniramine conventional versus controlled release products was conducted using 15 male subjects in a 3‐way crossover study with a 2‐week washout period between studies. The study was designed to determine if chlorpheniramine formulations provide consistent pharmacokinetic performance between individual units upon going from single dose to multiple dose therapy. In addition, the validity of predicting steady‐state levels for these kinds of products using only single oral dose data was examined. The dosage forms evaluated were a conventional 4mg tablet, and 8 mg barrier coated‐bead capsule, and an 8 mg repeat action tablet. Multiple doses of each product were orally administered to each subject for 6 days prior to the study day to achieve steady‐state levels and on the actual study day. Serum samples were collected at specific time intervals on the study day, and chlorpheniramine levels assayed by HPLC. Pharmacokinetic analysis was based on a two‐compartment open model. The mean plasma elimination half‐lives of the various dosage forms were in the range 24.5–25.4h. There was no rapid release of drug from the controlled r

Who reads Blood Levels Following Multiple Oral Dosing of Chlorpheniramine Conventional and Controlled Release Preparations?

Author

J. J. Vallner; J. A. Kotzan; J. T. Stewart; W. J. Brown; I. L. Honigberg; T. E. Needham; S. V. Dighe

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

1982

Language

EN

Field

Medicine (Health Sciences)