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Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors by Rajesh Subramaniam; Manas K. Haldar; Shakila Tobwala; Bratati Ganguly; D.K. Srivastava; Sanku Mallik is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors about?
A series of bis-(arylsulfonamide) hydroxamate inhibitors were synthesized. These compounds exhibit good potency against MMP-7 and MMP-9 depending on the nature, steric bulk, and substitution pattern of the substituents in the benzene ring. In general, the preliminary structure-activity relationships (SAR) suggest that among the DAPA hydroxamates (i) electron-rich benzene rings of the sulfonamides may produce better inhibitors than electron-poor analogs. However, potential H-bond acceptors can reverse the trend depending on the isozyme; (ii) isozyme selectivity between MMP-7 and -9 can be conferred through steric bulk and substitution pattern of the substituents in the benzene ring, and (iii) the MMP-10 inhibition pattern of the compounds paralleled that for MMP-9.
Who reads Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rajesh Subramaniam; Manas K. Haldar; Shakila Tobwala; Bratati Ganguly; D.K. Srivastava; Sanku Mallik
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)