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Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors: A comparison of direct smears and cell block preparations by Jing Liu; Anwar Farhood is a Medicine article available to read on EtoBox.

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## BACKGROUND. Fine-needle aspiration (FNA) is used commonly for the diagnosis of pulmonary neoplasms. It has been reported that thyroid transcription factor-1 (TTF-1) is a sensitive and specific marker for certain primary lung tumors. To the authors' knowledge, the use of TTF-1 immunostaining on FNA smears has not been documented in the literature. This study was designed to examine the utility of TTF-1 immunostaining on FNA specimens from various types of lung tumors by comparing the expression rates on Papanicolaou (Pap)-stained and Diff-Quik (DQ)-stained smears with the expression rates on cell block (CB) sections. ## METHODS. Forty-three FNA specimens of lung tumors were studied, including 34 primary tumors (14 adenocarcinomas, 12 squamous carcinomas, and 8 small cell carcinomas) and 9 metastatic tumors. One Pap-stained slide and one DQ-stained slide were selected from each tumor. The cytologic material from the slides was transferred to positively charged slides. Unstained recuts were obtained from the CB sections. All slides were stained with TTF-1 monoclonal antibody using heatinduced epitope retrieval and a labeled polymer detection system. ## RESULTS. Twelve of 14 pulmona

Who reads Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors: A comparison of direct smears and cell block preparations?

Author

Jing Liu; Anwar Farhood

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2004

Language

EN

Field

Medicine (Health Sciences)