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Release behavior of microspheres from cross-linked N-methylated chitosan encapsulated ofloxacin by Xianghong Peng; Lina Zhang; John F. Kennedy is a Materials Science article available to read on EtoBox.

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A series of hollow microspheres encapsulated with ofloxacin have been successfully prepared, using cyclohexane droplets as a template and the N-methylated chitosan (NMC) cross-linked with glutaraldehyde as the shell. The structure and morphology were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The swelling and releasing behaviors of the microspheres having different weight-average molecular weights (M w ) and the degree of quaternization of NMC at pH 1.2 and 7.4 media were investigated. The results revealed that microspheres exhibited a very smooth surface, and electrostatic interaction existed between cross-linked NMC and ofloxacin. Ofloxacin encapsulated in the microspheres was rapidly released into phosphate buffer solution (pH 7.4), whereas it was only slowly released in 0.1 M HCl (pH 1.2). The degree of swelling of microspheres at pH 7.4 was higher than that at pH 1.2. Moreover, ofloxacin was released more slowly from the microspheres having high M w of NMC than that with low M w . The release mechanism of the hollow microsphere was proposed to be a non-Fickan diffusion through the swollen microspheres, and to be controlled by the M w and t

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Author

Xianghong Peng; Lina Zhang; John F. Kennedy

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0144-8617)

Published

2006

Language

EN

Field

Materials Science (Physical Sciences)