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Association of induction of a fully tumorigenic phenotype in murine radiation‐induced T‐lymphoma cells with loss of differentiation antigens, gain of CD44, and alterations in p53 protein levels by Ruth A. Gjerset; Jyoti Arya; Sarah Volkman; Martin Haas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract We investigated the mechanism of radiation induction of murine thymic lymphomas by studying the characteristics of primary x‐ray–induced thymic lymphoma (PXTL) cell lines and of their oncogene‐induced, progressed progeny. It is widely thought that proto‐oncogene alterations are associated with the induction of murine lymphomas; however, few, if any primary murine radiation‐induced lymphomas possess (proto‐)oncogene alterations. Independently derived cell lines grown directly (i.e., without in vivo transplantation) from thymic lymphomas of irradiated C57BL/6 mice possess the properties of immortalized pre‐T cells and lack many of the characteristics of “tumor cells”. PXTL cells are poorly tumorigenic upon transplantation, do not clone in methylcellulose cultures, are growth factor dependent and autocrine, and lack consistent chromosome and oncogene abnormalities. However, the thymic lymphomas are malignant and cause the death of each afflicted mouse. PXTL cells expressed two immunologically distinct forms of the tumor suppressor protein p53 that have moderately increased stability (t~1/2~ = 1 h) when compared with p53 of normal splenic T lymphocytes. Early PXTL cells cou

Who reads Association of induction of a fully tumorigenic phenotype in murine radiation‐induced T‐lymphoma cells with loss of differentiation antigens, gain of CD44, and alterations in p53 protein levels?

Author

Ruth A. Gjerset; Jyoti Arya; Sarah Volkman; Martin Haas

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)