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Hepatitis C Virus Kinetics by Eva Herrmann; Avidan U Neumann; Jürgen M Schmidt; Stefan Zeuzem is a Medicine article available to read on EtoBox.

What is Hepatitis C Virus Kinetics about?

The balance of virus production and clearance for untreated patients with chronic hepatitis C virus (HCV) results in a decline of viraemia when initiating active antiviral treatment. During the first phase of interferon-α therapy, after a delay of about 8–9 h, the kinetics of the viral load is characterized by a rapid dose-dependent decline. This early response can be observed for almost all patients treated with interferon-α. After about 24–48 h, the viral decline enters a second phase of relatively slow exponential decay during the following weeks of therapy. Non-responding patients, however, show constant viraemia or even a rebound during this second phase. The rate of the exponential decline of the viral load in responding patients in this second phase is less sensitive to the dose of interferon-α and varies considerably among patients. Furthermore, combination therapy with interferon-α plus ribavirin does not significantly improve the initial viral decay, although it may prevent more patients from rebounding. Mathematical modelling of viral dynamics reveals high turnover rates of pre-treatment viral production and clearance, and permits the estimation of in vivo half-lives of

Who reads Hepatitis C Virus Kinetics?

Author

Eva Herrmann; Avidan U Neumann; Jürgen M Schmidt; Stefan Zeuzem

Publisher

SAGE Publications

Published

1999

Language

EN

Field

Medicine (Health Sciences)