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Hippocampal loss of tenascin boundaries in Ammon's horn sclerosis by Björn Scheffler; Andreas Faissner; Heinz Beck; Karsten Behle; Helmut K. Wolf; Otmar D. Wiestler; Ingmar Blümcke is a Neuroscience article available to read on EtoBox.

What is Hippocampal loss of tenascin boundaries in Ammon's horn sclerosis about?

Ammon's horn sclerosis (AHS) is a common finding in patients with temporal lobe epilepsy (TLE). In addition to selective neuronal cell loss and axonal reorganization, AHS is also characterized by a striking astroglial reaction. However, the functional significance of reactive astrogliosis in the pathogenesis of TLE remains to be determined. Reactive astrocytes produce a variety of cell adhesion molecules and other extracellular matrix (ECM) components with potential effects on axonal growth, axonal branching, and neosynaptogenesis in the central nervous system (CNS). In the present study we describe the distribution of the ECM glycoprotein tenascin/cytotactin (TN-C) in 44 human hippocampal specimens from patients with TLE. The distribution of TN-C immunoreactivity was evaluated with the anti-human TN-C monoclonal antibody K8 by densitometrical analysis, and TN-C protein levels were detected by immunoblotting. In the normal human hippocampus, there were distinctive boundaries between areas of high and low TN-C expression. These border zones demarcated areas with major synaptic input, i.e., the dentate gyrus molecular layer (DG-ML) and the gray matter of the Ammon's horn. TN-C and th

Who reads Hippocampal loss of tenascin boundaries in Ammon's horn sclerosis?

Author

Björn Scheffler; Andreas Faissner; Heinz Beck; Karsten Behle; Helmut K. Wolf; Otmar D. Wiestler; Ingmar Blümcke

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

1997

Language

EN

Field

Neuroscience (Life Sciences)