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A Chinese sailor: all at see by D.J. Sloan; M. Taegtmeyer; I.J. Hart; J. Pearce I.A. Darroch; N.J. Beeching; A.R.O. Miller is a Medicine article available to read on EtoBox.
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Background: Teicoplanin is widely used as a once-daily intravenous (iv) treatment regime in the treatment of serious gram positive infection, particularly in patients receiving parenteral antibiotics at home. It is suggested that a trough level of 20mg/L is required for successful treatment of staphylococcal endocarditis and septic arthritis. Monitoring of trough (pre-dose) levels is advocated to ensure that therapeutic concentrations are reached. Methods: We prospectively recorded data over 17 months (commencing April 2005) on consecutive adult patients receiving treatment with iv teicoplanin under the care of Oxford's Home IV Team. Teicoplanin levels were performed by the regional Antimicrobial Reference Lab (North Bristol NHS Trust). Common dose regimes used were either 400mg iv or 600mg iv daily, with an additional loading dose at 12 hours in both cases. Most patients received a total of 6 weeks of glycopeptide therapy. Results: 149 patient episodes are described (103 male, 46 female), age range 16-89, of whom 96% had musculoskeletal infection. The commonest pathogens being treated were coagulase negative staphylococci and Staphylococcus aureus. 3 patients received treatment wi
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- Author
- D.J. Sloan; M. Taegtmeyer; I.J. Hart; J. Pearce I.A. Darroch; N.J. Beeching; A.R.O. Miller
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)