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Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin system by Michal Herman-Edelstein; Tali Guetta; Amir Barnea; Maayan Waldman; Naomi Ben-Dor; Yaron D. Barac; Ran Kornowski; Michael Arad; Edith Hochhauser; Dan Aravot is a Medicine article available to read on EtoBox.
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## Background Diabetic and obese patients are at higher risk of severe disease and cardiac injury in corona virus 2 (SARS-CoV-2) infections. Cellular entry of SARS-CoV-2 is mainly via the angiotensin-converting enzyme 2 (ACE2) receptor, which is highly expressed in normal hearts. There is a disagreement regarding the effect of factors such as obesity and diabetes on ACE2 expression in the human heart and whether treatment with renin–angiotensin system inhibitors or anti-diabetic medications increases ACE2 expression and subsequently the susceptibility to infection. We designed this study to elucidate factors that control ACE2 expression in human serum, human heart biopsies, and mice. ## Methods Right atrial appendage biopsies were collected from 79 patients that underwent coronary artery bypass graft (CABG) surgery. We investigated the alteration in __ACE2__ mRNA and protein expression in heart tissue and serum. __ACE2__ expression was compared with clinical risk factors: diabetes, obesity and different anti-hypertensive or anti-diabetic therapies. WT or db/db mice were infused with Angiotensin II (ATII), treated with different anti-diabetic drugs (Metformin, GLP1A and SGLT2i) were
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- Author
- Michal Herman-Edelstein; Tali Guetta; Amir Barnea; Maayan Waldman; Naomi Ben-Dor; Yaron D. Barac; Ran Kornowski; Michael Arad; Edith Hochhauser; Dan Aravot
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)