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Can I read Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage on EtoBox?
Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage by Li Tian; Michael Stefanidakis; Lin Ning; Philippe Van Lint; Henrietta Nyman-Huttunen; Claude Libert; Shigeyoshi Itohara; Masayoshi Mishina; Heikki Rauvala; Carl G. Gahmberg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage about?
Matrix metalloproteinase (MMP)-2 and -9 are pivotal in remodeling many tissues. However, their functions and candidate substrates for brain development are poorly characterized. Intercellular adhesion molecule-5 (ICAM-5; Telencephalin) is a neuronal adhesion molecule that regulates dendritic elongation and spine maturation. We find that ICAM-5 is cleaved from hippocampal neurons when the cells are treated with __N__-methyl-d-aspartic acid (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA). The cleavage is blocked by MMP-2 and -9 inhibitors and small interfering RNAs. Newborn MMP-2– and MMP-9–deficient mice brains contain more full-length ICAM-5 than wild-type mice. NMDA receptor activation disrupts the actin cytoskeletal association of ICAM-5, which promotes its cleavage. ICAM-5 is mainly located in dendritic filopodia and immature thin spines. MMP inhibitors block the NMDA-induced cleavage of ICAM-5 more efficiently in dendritic shafts than in thin spines. ICAM-5 deficiency causes retraction of thin spine heads in response to NMDA stimulation. Soluble ICAM-5 promotes elongation of dendritic filopodia from wild-type neurons, but not from ICAM-5–deficient neurons. T
Who reads Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Li Tian; Michael Stefanidakis; Lin Ning; Philippe Van Lint; Henrietta Nyman-Huttunen; Claude Libert; Shigeyoshi Itohara; Masayoshi Mishina; Heikki Rauvala; Carl G. Gahmberg
- Publisher
- Rockefeller University Press|1
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)