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Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method by Elspeth M. Jack; Philip Bentley; Francoise Bieri; Samar F. Muakkassah-Kelly; Willy Stäubli; Joseph Suter; Felix Waechter; Luis M. Cruz-Orive is a Medicine article available to read on EtoBox.
What is Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method about?
Gamma-glutamyltranspeptidase-positive hepatocyte foci were produced in female rats given a single dose of diethylnitrosamine neonatally after birth and, after weaning, a diet containing phenobarbitone for 30 wk. The nucleator method, a new stereological approach, provided an efficient, unbiased estimate of mean cell volume in focal lesions and extrafocal areas. It also provided an unbiased sample of cells to estimate hepatocyte nuclear volume and the percentage of binucleated cells. The results showed an increase in the mean volume of mononucleated cells-from 4,700 pmS in extrafocal areas to 12,700 pm3 in foci-and of binucleated cells--from 6,900 pm3 to 25,000 pm3. This demonstrated the hypertrophic effect of the carcinogenic treatment in focal lesions. A striking reduction in the proportion of binucleated cells was also observed in the preneoplastic lesions. Nuclear volume measurements from mononucleated and binucleated hepatocytes were used to assess ploidy. An apparent increase in nuclear ploidy, with no change in cellular ploidy, was noted in focal tissue when compared with nonfocal tissue. This appeared to be caused by an increase in mononucleated tetraploid cells and a reduct
Who reads Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Elspeth M. Jack; Philip Bentley; Francoise Bieri; Samar F. Muakkassah-Kelly; Willy Stäubli; Joseph Suter; Felix Waechter; Luis M. Cruz-Orive
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Elsevier BV; Wiley; Research Square (ISSN 0270-9139)
- Published
- 1990
- Language
- EN
- Field
- Medicine (Health Sciences)