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Effects of Morphine and Nalorphine on Kainic Acid-induced Hypothermia in Rats by Lechosław Turski; Waldemar Turski; Stanisław J. Czuczwar; Zdzisław Kleinrok is a Neuroscience article available to read on EtoBox.

What is Effects of Morphine and Nalorphine on Kainic Acid-induced Hypothermia in Rats about?

Intraventricular administration of kainic acid at the dose of 0.1 pg induces a significant depression of rectal temperature followed rapidly by its slight elevation. Morphine (40.0 rag. kg-1 IP), which by itself elicited biphasic effect on the body temperature of rats-initially hypothermia followed by hyperthermia-slightly increased the kainic acid-induced hypothermia. Kainic acid did not cause any changes in the hyperthermic effect of low doses of morphine (10.0 rag. kg-1). Pretreatment of rats with nalorphine enhanced the kainic acid-induced hypothermia. On the contrary, nalorphine reversed the hypothermic effect produced by morphine at the dose of 40.0 mg.kg-2. The results suggest that morphine and kainic acidinduced hypothermia are not mediated by the influence on the same type of receptors.

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Author

Lechosław Turski; Waldemar Turski; Stanisław J. Czuczwar; Zdzisław Kleinrok

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1981

Language

EN

Field

Neuroscience (Life Sciences)