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The document summarizes the development and evaluation of orally disintegrating tablets containing loperamide hydrochloride. Loperamide has low bioavailability due to extensive first-pass metabolism. The study aimed to formulate fast-dissolving tablets using crospovidone as a superdisintegrant to improve dissolution and bioavailability. Tablets were prepared by direct compression and evaluated for properties like hardness, friability, disintegration time, and in-vitro drug release. Formulation F4 with 7.5%

Author

cinthiasetia

Language

EN