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Exploiting Natural Peptide Diversity: Novel Research Tools and Drug Leads by Knut Adermann; Harald John; Ludger Ständker; Wolf-Georg Forssmann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Exploiting Natural Peptide Diversity: Novel Research Tools and Drug Leads about?

During the course of evolution, nature has developed a vast number of peptides in all living and past species that display an exceeding diversity of structure and biological effects, such as hormonal and enzyme-controlling activity, communication between cells, and participation in host defence. Sensitive mass spectrometric technologies have been introduced and facilitate access to new natural peptides, even in trace amounts, and allow the quantitative determination of the peptide status of cells, organs and whole organisms (peptidomics). Among the large number of new biologically active peptides identified from an increasing variety of natural sources, regulators of ion channels, chemoattractants, protease inhibitors, metabolism-related hormones, cytotoxins, and antimicrobials have been found. These novel peptides serve as research tools and have potential as diagnostic biomarkers and for the development of peptide and peptidometic drugs.

Who reads Exploiting Natural Peptide Diversity: Novel Research Tools and Drug Leads?

Author

Knut Adermann; Harald John; Ludger Ständker; Wolf-Georg Forssmann

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0958-1669)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)