Can I read A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology on EtoBox?

A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology by Iglesias, Juan Eugenio; Insausti, Ricardo; Lerma-Usabiaga, Garikoitz; Bocchetta, Martina; Van Leemput, Koen; Greve, Douglas N; van der Kouwe, Andre; Fischl, Bruce; Caballero-Gaudes, Cesar; Paz-Alonso, Pedro M is a scholarly article available to read on EtoBox.

What is A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology about?

The human thalamus is a brain structure that comprises numerous, highly specific nuclei. Since these nuclei are known to have different functions and to be connected to different areas of the cerebral cortex, it is of great interest for the neuroimaging community to study their volume, shape and connectivity in vivo with MRI. In this study, we present a probabilistic atlas of the thalamic nuclei built using ex vivo brain MRI scans and histological data, as well as the application of the atlas to in vivo MRI segmentation. The atlas was built using manual delineation of 26 thalamic nuclei on the serial histology of 12 whole thalami from six autopsy samples, combined with manual segmentations of the whole thalamus and surrounding structures (caudate, putamen, hippocampus, etc.) made on in vivo brain MR data from 39 subjects. The 3D structure of the histological data and corresponding manual segmentations was recovered using the ex vivo MRI as reference frame, and stacks of blockface photographs acquired during the sectioning as intermediate target. The atlas, which was encoded as an adaptive tetrahedral mesh, shows a good agreement with with previous histological studies of the thalam

Author

Iglesias, Juan Eugenio; Insausti, Ricardo; Lerma-Usabiaga, Garikoitz; Bocchetta, Martina; Van Leemput, Koen; Greve, Douglas N; van der Kouwe, Andre; Fischl, Bruce; Caballero-Gaudes, Cesar; Paz-Alonso, Pedro M

Published

2018

Language

EN