Can I read Nanosized Biligated Metal–organic Framework Systems for Enhanced Cellular and Mitochondrial Sequential Targeting of Hepatic Carcinoma on EtoBox?

Nanosized Biligated Metal–organic Framework Systems for Enhanced Cellular and Mitochondrial Sequential Targeting of Hepatic Carcinoma by Kholoud K. Arafa; Mostafa Fytory; Shaker A. Mousa; Ibrahim M. El-Sherbiny is a scholarly article available to read on EtoBox.

What is Nanosized Biligated Metal–organic Framework Systems for Enhanced Cellular and Mitochondrial Sequential Targeting of Hepatic Carcinoma about?

Mitochondria are reported to play a paramount role in tumorigenesis which positions them as an instrumental druggable target. However, selective drug delivery to cancer-localized mitochondria remains challenging. Herein, we report for the first time, the design, development and evaluation of a hepatic cancer-specific mitochondria-targeted dual ligated nanoscale metal-organic framework (NMOF) for cellular and mitochondrial sequential drug delivery. Surface functionalization was performed through covalent-linking of folic acid and triphenylphosphonium moieties to the aminated Zr-based MOF, NH-UiO-66. The characterization of the dual-ligated NMOFs using XRD, FTIR, DSC and BET analysis proved the successful conjugation process. Assessment of the drug loading and release profiling of doxorubicin (DOX)-loaded NMOF confirmed the proper retention of the drug within the NMOF porous structure alongside enhanced release in the tumor acidic environment. Furthermore, biological evaluation of the anti-tumor activity of the DOX-loaded dual-ligated NMOF on hepatocellular carcinoma affirmed the superiority of the developed system in killing the cancerous cells apoptosis induction and halting cell c

Author

Kholoud K. Arafa; Mostafa Fytory; Shaker A. Mousa; Ibrahim M. El-Sherbiny

Publisher

Royal Society of Chemistry (RSC)

Published

2021

Language

EN