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Epidermal Growth Factor Is Critical for Intestinal Adaptation Following Small Bowel Resection by Lawrence E. Stern; Christopher R. Erwin; David P. O'Brien; Frederick Huang; Brad W. Warner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Epidermal Growth Factor Is Critical for Intestinal Adaptation Following Small Bowel Resection about?

The loss of small intestinal mucosal surface area is a relatively common clinical situation seen in both the pediatric and adult population. The most frequent causes include mesenteric ischemia, trauma, inflammatory bowel disease, necrotizing enterocolitis, and volvulus. Following surgical resection, the remnant intestine compensates or adapts to the loss of native bowel by increasing its absorptive surface area and functional capacity. Unfortunately, many patients fail to adapt adequately, and are relegated to lifelong intravenous nutrition. Research into intestinal adaptation following small bowel resection (SBR) has evolved only recently from the gross and microscopic level to the biochemical and genetic level. As understanding of this process has increased, numerous therapeutic strategies to augment adaptation have been proposed. Epidermal growth factor (EGF) is an endogenous peptide that is secreted into the gastrointestinal tract and able to influence gut ontogeny, as well as mucosal healing. Early studies have demonstrated its ability to augment the adaptive process. Focusing on a murine model of massive intestinal loss, the morphological, structural, biochemical, and geneti

Who reads Epidermal Growth Factor Is Critical for Intestinal Adaptation Following Small Bowel Resection?

Author

Lawrence E. Stern; Christopher R. Erwin; David P. O'Brien; Frederick Huang; Brad W. Warner

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1059-910X)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)