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## Levetiracetam/valproic-acid Agitation, confusion and lack of efficacy: case report An 10-year-old boy exhibited lack of efficacy during treatment with levetiracetam for status epilepticus. Additionally, he developed agitation and confusion during treatment with valproic-acid for the status epilepticus [not all dosages stated; routes, duration of treatments to reaction onsets and outcomes not stated]. The boy presented with absence seizures at the age of nine years. His parents refused treatment with medications, and started a self-formulated ketogenic diet with partial control. At the age of 10 years, he experienced first generalised tonic-clonic seizure (GTCS). Hence, treatment with levetiracetam 100 mg/kg/day was started along with the ongoing ketogenic diet; however, his seizures remained uncontrolled with infrequent GTCS and daily absence seizure. Also, he was unable to achieve ketosis on the diet. He was hospitalised twice due to status epilepticus. A loading dose of valproic acid, caused confusion and agitation. Therefore, valproic acid therapy was stopped. Phenytoin was added to the boy's ongoing levetiracetam 1000mg bid (60 mg/kg/day) therapy. He also received a five day

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Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)