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Repair of gastric ulcer: A cell kinetic study by B. Helpap; T. Hattori; P. Gedigk is a Medicine article available to read on EtoBox.

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By a cryosurgical method a mucosal defect was produced in the body of the rat stomach, and repair of the gastric ulcer was studied with 3H-thymidine autoradiography. From 18 to 24 hours after cryoinjury, cell proliferation in the fundic mucosa was much increased, as indicated by an increase in the labeling index of the cells in the proliferating cell zone of the mucosa, or by reactive incorporation of 3H-thymidine into the mucous neck, chief and parietal cells. Spatially, the increased cell proliferation was found in a region of the mucosa more than 600 ~tm distant from the injury, and lasted for more than 14 days. The mucous neck and chief cells around the ulcer which had incorporated 3H-thymidine seemed to transform into fiat cells after mitotic division and then continued to divide. After 3-5 days, so called regenerating epithelium or covering epithelium appeared around the ulcer. The upper part of this regenerating epithelium consists of tall columnar cells, the lower part is composed of cystic glandular structures, in which many 3H-thymidine incorporating cells were seen. The formation of new glands in the mucosal defect appeared to take place by budding from these cystic glan

Who reads Repair of gastric ulcer: A cell kinetic study?

Author

B. Helpap; T. Hattori; P. Gedigk

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1981

Language

EN

Field

Medicine (Health Sciences)