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Nonalcoholic Fatty Liver Disease—A Concise Review of Noninvasive Tests and Biomarkers by Tamara Bassal; Maamoun Basheer; Mariana Boulos; Nimer Assy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nonalcoholic Fatty Liver Disease—A Concise Review of Noninvasive Tests and Biomarkers about?

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with a continuously growing prevalence. The pathophysiology of the disease is complex and includes several mechanisms, with metabolic syndrome and insulin resistance playing a major role. It is crucial to diagnose NAFLD before it advances to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis, presented by its complications which include ascites, portal hypertension, bleeding varices and encephalopathy. Another important complication of NAFLD and cirrhosis is hepatocellular carcinoma (HCC), a cancer with increasing incidence and poor prognosis. Even with the growing prevalence of NAFLD, diagnosis via liver biopsies is unrealistic, considering the costs and complications. Noninvasive tests, including serum biomarkers and elastography, are cost-effective and convenient, thereby replacing liver biopsies in diagnosing and excluding liver fibrosis. However, currently, these noninvasive tests have several limitations, such as variability, inadequate accuracy and risk factors for error. The limitations and variability of these tests comet the investigator to propose combining them in dia

Who reads Nonalcoholic Fatty Liver Disease—A Concise Review of Noninvasive Tests and Biomarkers?

Author

Tamara Bassal; Maamoun Basheer; Mariana Boulos; Nimer Assy

Publisher

MDPI AG

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)