Can I read In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: Correlation with somatostatin and dopamine D~2~ receptor scintigraphy on EtoBox?

In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: Correlation with somatostatin and dopamine D~2~ receptor scintigraphy by Diego Ferone; Rosario Pivonello; Secondo Lastoria; Antongiulio Faggiano; Maria Laura Del Basso de Caro; Paolo Cappabianca; Gaetano Lombardi; Annamaria Colao is a Medicine article available to read on EtoBox.

What is In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: Correlation with somatostatin and dopamine D~2~ receptor scintigraphy about?

**OBJECTIVE** GH and PRL cosecretion frequently occurs in acromegaly and the sensitivity of both hormones to somatostatin analogs (SA) and dopamine agonists (DA) alone or in combination, is still debated. This study was designed to evaluate the __in vivo__ and __in vitro__ sensitivity to SA and/or DA and correlate the response in terms of hormone suppression to the results of __in vivo__ somatostatin and dopamine receptor scintigraphy and to the immunohistochemical findings. **DESIGN AND PATIENTS** Scintigraphy using ^111^In‐DTPA‐D‐Phe^1^‐OCT (^111^In‐OCT) and ^123^I‐methoxybenzamide (^123^I‐IBZM) was performed in four patients with acromegaly and high circulating GH, PRL and IGF‐I levels. The results were correlated with the response to long‐term treatment with octreotide (OCT), quinagolide (QN) and/or cabergoline (CAB), to the __**in vitro**__ hormone suppression by OCT and DA in primary cultures from the pituitary tumors and to the immunohistochemical findings. **RESULTS** The first patient showed high tumour uptake of ^111^In‐OCT and ^123^I‐IBZM, the second high uptake of only ^111^In‐OCT, while the third one showed faint tumour uptake of only ^123^I‐IBZM, and the fourth a fain

Who reads In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: Correlation with somatostatin and dopamine D~2~ receptor scintigraphy?

Author

Diego Ferone; Rosario Pivonello; Secondo Lastoria; Antongiulio Faggiano; Maria Laura Del Basso de Caro; Paolo Cappabianca; Gaetano Lombardi; Annamaria Colao

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2001

Language

EN

Field

Medicine (Health Sciences)