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Can I read Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2) on EtoBox?
Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2) by María del Pilar Corral; Olaya Villa; Elizabeth M. Alfaro; Cristina N. Alonso; Cristina Baro; Maria S. Felice; Jorge Rossi; Francesc Solé; Marta S. Gallego is a Medicine article available to read on EtoBox.
What is Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2) about?
## Abstract We present a case of acute myeloblastic leukemia (AML‐M2) with a complex t(8;21) translocation and additional acquired chromosomes yielding a hyperdiploid karyotype. __AML1__/__ETO__ transcript was observed by reverse transcription‐polymerase chain reaction. Fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), and comparative genomic hybridization (CGH) were performed to further identify the chromosomes observed by G banding. The patient was treated according to our current protocol for AML. He remains in complete remission +11 months from diagnosis. Further follow‐up of this patient and the analysis of a larger number of children are needed to define whether the gains of the specific extra chromosomes modify the good prognosis that t(8;21) confers to this subgroup of AML. Pediatr Blood Cancer 2008;50:651–654. © 2007 Wiley‐Liss, Inc.
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- Author
- María del Pilar Corral; Olaya Villa; Elizabeth M. Alfaro; Cristina N. Alonso; Cristina Baro; Maria S. Felice; Jorge Rossi; Francesc Solé; Marta S. Gallego
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)