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SUBA-Itraconazole for Primary Antifungal Prophylaxis After Allogeneic Hematopoietic Cell Transplantation by Julian Lindsay; Jad Othman; Yvonne Kong; Annie Yip; Sebastiaan Van Hal; Stephen Larsen; Christian Bryant; John Gibson; Ian Kerridge; Keith Fay; William Stevenson; Chris Arthur; Sharon C A Chen; David C M Kong; Matthew Greenwood; Steven A Pergam; Catherine Liu; Monica A Slavin is a Medicine article available to read on EtoBox.
What is SUBA-Itraconazole for Primary Antifungal Prophylaxis After Allogeneic Hematopoietic Cell Transplantation about?
## Abstract ## Background Itraconazole (ITZ) is an effective agent when used as primary invasive fungal disease (IFD) prophylaxis, but is limited by drug tolerability and variability in serum concentrations. A new formulation, SUBA-itraconazole (for “super bioavailability”; S-ITZ), addresses the limitations of conventional ITZ formulations. ## Methods We conducted a retrospective cohort study at 2 Australian centers to evaluate the safety, tolerability, and effectiveness of S-ITZ as primary antifungal prophylaxis in hematopoietic cell transplant (HCT) recipients without grade II–IV acute graft-vs-host disease, from day 1 until approximately day 100 (cohort A) or day 1 until neutrophil engraftment (cohort B). A total of 204 patients and 1410 trough plasma ITZ concentrations were assessed. ## Results The incidence of breakthrough proven/probable IFD at day 180 was 1.0% (95% confidence interval [CI], .2%–3.2%), with 1.6% in cohort A and 0% in cohort B, and overall fungal-free survival of proven/probable IFD was 82.9% (95% CI, 76.8%–87.4%). Preengraftment early permanent S-ITZ discontinuation was 3.4% overall, with no significant difference between cohorts. No patients required cessati
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- Author
- Julian Lindsay; Jad Othman; Yvonne Kong; Annie Yip; Sebastiaan Van Hal; Stephen Larsen; Christian Bryant; John Gibson; Ian Kerridge; Keith Fay; William Stevenson; Chris Arthur; Sharon C A Chen; David C M Kong; Matthew Greenwood; Steven A Pergam; Catherine Liu; Monica A Slavin
- Publisher
- Oxford University Press
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)