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Development, spread and persistence of antibiotic resistance genes (ARGs) in the soil microbiomes through co-selection by Anand Prakash Maurya; Jina Rajkumari; Amitabha Bhattacharjee; Piyush Pandey is a scholarly article available to read on EtoBox.

What is Development, spread and persistence of antibiotic resistance genes (ARGs) in the soil microbiomes through co-selection about?

## Abstract Bacterial pathogens resistant to multiple antibiotics are emergent threat to the public health which may evolve in the environment due to the co-selection of antibiotic resistance, driven by poly aromatic hydrocarbons (PAHs) and/or heavy metal contaminations. The co-selection of antibiotic resistance (AMR) evolves through the co-resistance or cross-resistance, or co-regulatory mechanisms, present in bacteria. The persistent toxic contaminants impose widespread pressure in both clinical and environmental setting, and may potentially cause the maintenance and spread of antibiotic resistance genes (ARGs). In the past few years, due to exponential increase of AMR, numerous drugs are now no longer effective to treat infectious diseases, especially in cases of bacterial infections. In this mini-review, we have described the role of co-resistance and cross-resistance as main sources for co-selection of ARGs; while other co-regulatory mechanisms are also involved with cross-resistance that regulates multiple ARGs. However, co-factors also support selections, which results in development and evolution of ARGs in absence of antibiotic pressure. Efflux pumps present on the same mo

Author

Anand Prakash Maurya; Jina Rajkumari; Amitabha Bhattacharjee; Piyush Pandey

Publisher

Walter de Gruyter GmbH

Published

2020

Language

EN