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Synthesis of Pyrrolo[2,3-d]pyrimidine Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line by Myung-Ho Jung; Hwan Kim; Won-Kyoung Choi; Mohammed I. El-Gamal; Jin-Hun Park; Kyung Ho Yoo; Tae Bo Sim; So Ha Lee; Daejin Baek; Jung-Mi Hah; Jung-Hyuck Cho; Chang-Hyun Oh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis of Pyrrolo[2,3-d]pyrimidine Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line about?
Synthesis of a new series of diarylureas and amides having pyrrolo[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against A375 human melanoma cell line and HS 27 fibroblast cell line were tested and the effect of substituents on pyrrolo[2,3-d]pyrimidine was investigated. The newly synthesized compounds, except N-acetyl derivatives (Id, Ie, and Im), generally showed superior or similar activity against A375 to Sorafenib. Among all of these derivatives, compounds Iq and Ir having imidazole and morpholine moieties, respectively, showed the most potent antiproliferative activity against A375.
Who reads Synthesis of Pyrrolo[2,3-d]pyrimidine Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Myung-Ho Jung; Hwan Kim; Won-Kyoung Choi; Mohammed I. El-Gamal; Jin-Hun Park; Kyung Ho Yoo; Tae Bo Sim; So Ha Lee; Daejin Baek; Jung-Mi Hah; Jung-Hyuck Cho; Chang-Hyun Oh
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)