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Insulin Resistance, the Metabolic Syndrome, and Complication Risk in Type 1 Diabetes by Eric S. Kilpatrick; Alan S. Rigby; Stephen L. Atkin is a Medicine article available to read on EtoBox.

What is Insulin Resistance, the Metabolic Syndrome, and Complication Risk in Type 1 Diabetes about?

OBJECTIVE—The presence of insulin resistance and the metabolic syndrome are known risk markers for macrovascular disease in patients with and without type 2 diabetes. This study has examined whether these also were predictors of micro- and macrovascular complications in type 1 diabetic patients participating in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS—International Diabetes Federation (IDF) criteria were used to identify the metabolic syndrome in 1,337 Caucasian DCCT patients at baseline. Insulin resistance was calculated using their estimated glucose disposal rate (eGDR). Insulin dose (units/kg) was also used as a separate marker of insulin resistance. RESULTS—The eGDR (but not insulin dose or metabolic syndrome) at baseline strongly predicted the development of retinopathy, nephropathy, and cardiovascular disease (hazard ratios 0.75, 0.88, and 0.70, respectively, per mg · kg−1 · min−1 change; P < 0.001, P = 0.005, and P = 0.002, respectively). Through mainly weight gain, the prevalence of the metabolic syndrome increased steadily from baseline to year 9 in conventionally treated (from 15.5 to 27.2%) and especially in the intensively treated

Who reads Insulin Resistance, the Metabolic Syndrome, and Complication Risk in Type 1 Diabetes?

Author

Eric S. Kilpatrick; Alan S. Rigby; Stephen L. Atkin

Publisher

American Diabetes Association; Publons (ISSN 0149-5992)

Published

2007

Language

EN

Field

Medicine (Health Sciences)