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Can I read Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors on EtoBox?
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors by Wei-Bin Wu; Jie-Bin Ou; Zhi-Hong Huang; Shuo-Bin Chen; Tian-Miao Ou; Jia-Heng Tan; Ding Li; Liu-Lan Shen; Shi-Liang Huang; Lian-Quan Gu; Zhi-Shu Huang is a Chemistry article available to read on EtoBox.
What is Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors about?
A series of mansonone F (MF) derivatives were designed and synthesized. These compounds were found to be strong inhibitors for topoisomerases, with much more significant inhibition for topoisomerase II rather than topoisomerase I. The best inhibitor showed 20 times stronger anti-topoisomerase II activity than a positive control Etoposide. The cytotoxic activity of these MF derivatives was evaluated against human cancer cell lines CNE-2 and Glc-82, which showed that these compounds were potent antitumor agents. The structureeactivity relationships (SARs) study revealed that o-quinone group and pyran ring are important for their cytotoxic activity.
Who reads Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Wei-Bin Wu; Jie-Bin Ou; Zhi-Hong Huang; Shuo-Bin Chen; Tian-Miao Ou; Jia-Heng Tan; Ding Li; Liu-Lan Shen; Shi-Liang Huang; Lian-Quan Gu; Zhi-Shu Huang
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2011
- Language
- EN
- Field
- Chemistry (Physical Sciences)