Can I read Children's Oncology Group's 2023 blueprint for research: Germ cell tumors on EtoBox?

Children's Oncology Group's 2023 blueprint for research: Germ cell tumors by Roma Bhuta; Rachana Shah; Joanna J. Gell; Jenny N. Poynter; Aditya Bagrodia; Bryan J. Dicken; Farzana Pashankar; A Lindsay Frazier; Furqan Shaikh is a Medicine article available to read on EtoBox.

What is Children's Oncology Group's 2023 blueprint for research: Germ cell tumors about?

## Abstract Extracranial germ cell tumors (GCT) are a biologically diverse group of tumors occurring in children, adolescents, and young adults. The majority of patients have excellent outcomes, but treatment‐related toxicities impact their quality of survivorship. A subset of patients succumbs to the disease. Current unmet needs include clarifying which patients can be safely observed after initial surgical resection, refinement of risk stratification to reduce chemotherapy burden in patients with standard‐risk disease, and intensify therapy for patients with poor‐risk disease. Furthermore, enhancing strategies for detection of minimal residual disease and early detection of relapse, particularly in serum tumor marker‐negative histologies, is critical. Improving the understanding of the developmental and molecular origins of GCTs may facilitate discovery of novel targets. Future efforts should be directed toward assessing novel therapies in a biology‐driven, biomarker‐defined, histology‐specific, risk‐stratified patient population. Fragmentation of care between subspecialists restricts the unified study of these rare tumors. It is imperative that trials be conducted in collaborati

Who reads Children's Oncology Group's 2023 blueprint for research: Germ cell tumors?

Author

Roma Bhuta; Rachana Shah; Joanna J. Gell; Jenny N. Poynter; Aditya Bagrodia; Bryan J. Dicken; Farzana Pashankar; A Lindsay Frazier; Furqan Shaikh

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)