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Synthetic studies toward astins A, B and C. Efficient syntheses of cis-3,4-dihydroxyprolines and (−)-(3S,4R)-dichloroproline esters by Kelly K. Schumacher; Jianjun Jiang; Madeleine M. Joullié is a scholarly article available to read on EtoBox.

What is Synthetic studies toward astins A, B and C. Efficient syntheses of cis-3,4-dihydroxyprolines and (−)-(3S,4R)-dichloroproline esters about?

Efficient syntheses of the esters of cis-3,4-dihydroxyprolines and the first synthesis of the ester of the rare amino acid (-)-(3S,4R)-dichloroproline from trans-4-hydroxy-L-proline are presented. The synthetic route provides easy access to several substituted prolines and cis-hydroxylated proline esters. Various types of biological activities have been associated with these substituted prolines. The role of (-)-(3S,4R)-dichloroproline in astins A, B and C is under investigation.

Author

Kelly K. Schumacher; Jianjun Jiang; Madeleine M. Joullié

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0957-4166)

Published

1998

Language

EN