Opening book details…
Can I read Maternal-fetal Disposition of Domoic Acid Following Repeated Oral Dosing During Pregnancy in Nonhuman Primate on EtoBox?
Maternal-fetal Disposition of Domoic Acid Following Repeated Oral Dosing During Pregnancy in Nonhuman Primate by Shum, Sara; Jing, Jing; Petroff, Rebekah; Crouthamel, Brenda; Grant, Kimberly S.; Burbacher, Thomas M.; Isoherranen, Nina is a Environmental Science article available to read on EtoBox.
What is Maternal-fetal Disposition of Domoic Acid Following Repeated Oral Dosing During Pregnancy in Nonhuman Primate about?
Domoic acid (DA) is a marine algal toxin that causes acute and chronic neurotoxicity in animals and humans. Prenatal exposure to DA has been associated with neuronal damage and cognitive and behavioral deficits in juvenile California sea lions, cynomolgus monkeys and rodents. Yet, the toxicokinetics (TK) of DA during pregnancy and the maternal-fetal disposition of DA have not been fully elucidated. In this study, we investigated the TK before, during, and after pregnancy and the maternal-fetal disposition of DA in 22 cynomolgus monkeys following daily oral doses of 0.075 or 0.15 mg/kg/day of DA. The AUC of DA was not changed while the renal clearance of DA was increased by 30-90% during and after pregnancy when compared to the pre-pregnancy values. DA was detected in the infant plasma and in the amniotic fluid at delivery. The infant plasma concentrations correlated positively with both the maternal plasma and the amniotic fluid concentrations. The paired infant-to-maternal plasma DA concentration ratios ranged from 0.3 to 0.6 and increased as a function of time which suggests placental efflux and longer apparent fetal half-life than the maternal half-life. The paired amniotic flui
Who reads Maternal-fetal Disposition of Domoic Acid Following Repeated Oral Dosing During Pregnancy in Nonhuman Primate?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Shum, Sara; Jing, Jing; Petroff, Rebekah; Crouthamel, Brenda; Grant, Kimberly S.; Burbacher, Thomas M.; Isoherranen, Nina
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0041-008X)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Life Sciences)