Can I read P4HA2 contributes to cervical cancer progression via inducing epithelial-mesenchymal transition on EtoBox?

P4HA2 contributes to cervical cancer progression via inducing epithelial-mesenchymal transition by Cao, Yuan; Han, Qicai; Li, Juan; Jia, Yanyan; Zhang, Ruitao; Shi, Huirong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is P4HA2 contributes to cervical cancer progression via inducing epithelial-mesenchymal transition about?

**Background:** Cervical cancer is one of the most common gynaecological malignancies. Emerging studies have documented that prolyl-4-hydroxylase α subunit 2 (P4HA2) is involved in multiple processes of cancer progression. However, the functional roles of P4HA2 in cervical cancer progression remain to be elucidated. **Methods:** P4HA2 mRNA and protein levels were examined in cervical cancer tissues and cell line by qRT-PCR and western blot. The correlation of the P4HA2 expression levels and prognosis of cervical cancer patients were analysed in TCGA cervical cancer cohort and tissue microarray (TMA) cohort. P4HA2 was silenced to evaluate its function on cervical cancer progression both __in vitro__ and __in vivo__. Bioinformatics analysis was performed to investigate the underlying regulation mechanism of cervical cancer by P4HA2. **Results:** We found that P4HA2 are markedly upregulated in cervical cancer tissues in comparison with adjacent non-neoplastic tissues. In addition, upregulation of P4HA2 was associated with shorter overall survival (OS) and relapse-free survival (RFS). Functionally, we demonstrated that P4HA2 knockdown attenuated cell proliferation, migration and invasi

Who reads P4HA2 contributes to cervical cancer progression via inducing epithelial-mesenchymal transition?

Author

Cao, Yuan; Han, Qicai; Li, Juan; Jia, Yanyan; Zhang, Ruitao; Shi, Huirong

Publisher

Ivyspring International Publisher; Wyoming N.S.W.: Ivyspring International Publisher, 2010- (ISSN 1837-9664)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)