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Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy resistance by Chunjuan Zheng; Wenjuan Luo; Yu Liu; Jiashe Chen; Hui Deng; Zaigang Zhou; Jianliang Shen is a Engineering article available to read on EtoBox.

What is Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy resistance about?

Nowadays, photodynamic therapy (PDT) has become a novel effect modality for cancer therapy. But, facing the extremely hypoxic tumor microenvironment, the efficacy of PDT is still impaired owing to the limited reactive oxygen species (ROS) production. Moreover, after PDT, the overexpression of programmed cell death-ligand 1 (PD-L1) and indoleamine-2,3-dioxygenase-1 (IDO1) could trigger the following impaired T cell infiltration and the further lowered anti-tumor immunity mediated by T cells. Regrettably, up to now, no simple nanosystem could solve these defects of PDT simultaneously and economically. To ameliorate such a situation, we rationally designed and prepared clinically usable hypoxia reversing berberine liposome (BBR@IR68-Lip) with PD-L1 and IDO1 dual-depression capacity simultaneously to overcome photodynamic immunotherapy resistance. In this nanosystem, BBR@IR68-Lip was constructed by using near-infrared photodynamic dye IR68 chemically modified DSPE-PEG 2000 with tumor-targeting capacity as liposome component to encapsulate berberine (BBR) as a novel tumor oxygen and immune microenvironment regulation drug. Owing to the tumor-targeting capacity of IR68-Lip, the accumulat

Who reads Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy resistance?

Author

Chunjuan Zheng; Wenjuan Luo; Yu Liu; Jiashe Chen; Hui Deng; Zaigang Zhou; Jianliang Shen

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)