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Antioxidant and angiotensin-converting enzyme (ACE) inhibitory activity of thymosin alpha-1 (Thα1) peptide by Jasmin Kharazmi-Khorassani; Ahmad Asoodeh; Hamid Tanzadehpanah is a Chemistry article available to read on EtoBox.

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In this research, the antioxidant property of thymosin alpha-1 (Thα1) peptide was investigated through various antioxidant methods. Thα1 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (IC = 20 μM) and its 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging reached 45.33% at 80 μM (IC = 85 μM). In addition, hydroxyl and superoxide radical scavenging of Thα1 peptide exhibited a concentration-depended manner. The IC values of hydroxyl and superoxide radical scavenging were estimated to be 82 μM and 20 μM, respectively. The effect of Thα1 on eliminating superoxide radicals was higher (62.23%) than other antioxidant assays. Moreover, the antioxidant activity of Thα1 peptide was evaluated by measuring cellular reactive oxygen species (ROS). Results indicated that Thα1 decreased the generation of ROS level in 1321 N1 human neural asterocytoma cells. The inhibitory effect of Thα1 on angiotensin-converting enzyme (ACE) was determined. The kinetic parameters (K and V) and the inhibition pattern were examined. Based on the Lineweaver-Burk plot, Thα1 displayed a mixed inhibition pattern. The IC and K values of Thα1 were 0.8 μM and 3.33 μM, respect

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Author

Jasmin Kharazmi-Khorassani; Ahmad Asoodeh; Hamid Tanzadehpanah

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0045-2068)

Published

2019

Language

EN

Field

Chemistry (Physical Sciences)