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Parathyroid Hormone Therapy for Managing Chronic Hypoparathyroidism: A Systematic Review and Meta‐Analysis by Liang Yao; Jing Li; Meixuan Li; Clement Lin; Xu Hui; Divyalakshmi Tamilselvan; Maryam Kandi; Ashwini Sreekanta; Nima Makhdami; Dalal S. Ali; Karel Dandurand; Kehu Yang; John P. Bilezikian; Maria Luisa Brandi; Bart L. Clarke; Michael Mannstadt; Lars Rejnmark; Aliya A. Khan; Gordon Guyatt is a Medicine article available to read on EtoBox.
What is Parathyroid Hormone Therapy for Managing Chronic Hypoparathyroidism: A Systematic Review and Meta‐Analysis about?
## ABSTRACT The efficacy and safety of parathyroid hormone (PTH) therapy for managing long‐term hypoparathyroidism is being evaluated in ongoing clinical trials. We undertook a systematic review and meta‐analysis of currently available randomized controlled trials to investigate the benefits and harms of PTH therapy and conventional therapy in the management of patients with chronic hypoparathyroidism. To identify eligible studies, published in English, we searched Embase, PubMed, and Cochrane CENTRAL from inception to May 2022. Two reviewers independently extracted data and assessed the risk of bias. We defined patients' important outcomes and used grading of recommendations, assessment, development, and evaluation (GRADE) to provide the structure for quantifying absolute effects and rating the quality of evidence. Seven randomized trials of 12 publications that enrolled a total of 386 patients proved eligible. The follow‐up duration ranged from 1 to 36 months. Compared with conventional therapy, PTH therapy probably achieves a small improvement in physical health‐related quality of life (mean difference [MD] 3.4, 95% confidence interval [CI] 1.5–5.3, minimally important differenc
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- Author
- Liang Yao; Jing Li; Meixuan Li; Clement Lin; Xu Hui; Divyalakshmi Tamilselvan; Maryam Kandi; Ashwini Sreekanta; Nima Makhdami; Dalal S. Ali; Karel Dandurand; Kehu Yang; John P. Bilezikian; Maria Luisa Brandi; Bart L. Clarke; Michael Mannstadt; Lars Rejnmark; Aliya A. Khan; Gordon Guyatt
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)