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The Structure of the Hematopoietic System Can Explain Chronic Myeloid Leukemia Progression by Pérez-Jiménez, Mario (author);Derényi, Imre (author);Szöllősi, Gergely J. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Structure of the Hematopoietic System Can Explain Chronic Myeloid Leukemia Progression about?

Almost all cancer types share the hallmarks of cancer and a similar tumor formation: fueled by stochastic mutations in somatic cells. In case of chronic myeloid leukemia (CML), this evolutionary process can be tracked from an asymptomatic long-lasting chronic phase to a final rapidly evolving blast phase. Somatic evolution in CML occurs in the context of healthy blood production, a hierarchical process of cell division; initiated by stem cells that self-renew and differentiate to produce mature blood cells. Here we introduce a general model of hierarchical cell division explaining the particular progression of CML as resulting from the structure of the hematopoietic system. Driver mutations confer a growth advantage to the cells carrying them, for instance, the __BCR::ABL1__ gene, which also acts as a marker for CML. We investigated the relation of the __BCR::ABL1__ mutation strength to the hematopoietic stem cell division rate by employing computer simulations and fitting the model parameters to the reported median duration for the chronic and accelerated phases. Our results demonstrate that driver mutations (additional to the __BCR::ABL1__ mutation) are necessary to explain CML p

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Author

Pérez-Jiménez, Mario (author);Derényi, Imre (author);Szöllősi, Gergely J. (author)

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)