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What is ECM Disorganization in OSCC Carcinogenesis about?

This study investigates the progressive changes in the extracellular matrix (ECM) during 4-nitroquinoline-1-oxide (4NQO)-induced oral squamous cell carcinoma (OSCC) in mice. The findings reveal that there is a significant destruction of the basal lamina and disorganization of collagen I in the connective tissue as the disease progresses from mild dysplasia to invasive carcinoma. These results validate the use of the 4NQO model for studying tumor pathogenesis and highlight the alterations in ECM associated w

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[email protected]

Language

EN