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Activity-Guided Isolation of Scopoletin and Isoscopoletin, the Inhibitory Active Principles towards CCRF-CEM Leukaemia Cells and Multi-Drug Resistant CEM/ADR5000 Cells, from Artemisia argyi by Michael Adams; Thomas Efferth; Rudolf Bauer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Activity-Guided Isolation of Scopoletin and Isoscopoletin, the Inhibitory Active Principles towards CCRF-CEM Leukaemia Cells and Multi-Drug Resistant CEM/ADR5000 Cells, from Artemisia argyi about?

In a preliminary screening of traditional Chinese medicinal (TCM) herbal drugs for anti-proliferation activity against CCRF-CEM leukaemia cells, the ethyl acetate extract of leaves of Artemisia argyi (Juss.) Benth. (Asteraceae) showed considerable activity. Bioassayguided fractionation by chromatographic methods using CCRF-CEM cells led to the isolation of the active coumarins scopoletin and isoscopoletin. The pharmacological activity of the pure substances was evaluated against CCRF-CEM leukaemia cells and their multidrug resistant subline, CEM/ADR5000. This drug is officially listed in the Chinese pharmacopoeia [1] as aAijeo and is used in TCM as an analgesic and haemostatic and in moxibustion. It contains a number of monoterpenes, sesquiterpenes, triterpenes, coumarins and flavones [2]. Dried, finely ground leaves (200 g) were Soxhlet-extracted with n-hexane (p. a.) for 5 hours, yielding 6.3 g of extract. The extract-

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Author

Michael Adams; Thomas Efferth; Rudolf Bauer

Publisher

Thieme Medical Publishers; Georg Thieme Verlag KG; Georg Thieme Verlag (ISSN 0032-0943)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)