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HMGB1 is a bone‐active cytokine by Jieping Yang; Rita Shah; Alexander G. Robling; Evan Templeton; Huan Yang; Kevin J. Tracey; Joseph P. Bidwell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is HMGB1 is a bone‐active cytokine about?

## Abstract High mobility __g__roup __b__ox 1 (HMGB1) is a chromatin protein that acts as an immunomodulatory cytokine upon active release from myeloid cells. HMGB1 is also an alarmin, an endogenous molecule released by dying cells that acts to initiate tissue repair. We have previously reported that osteoclasts and osteoblasts release HMGB1 and release by the latter is regulated by parathyroid hormone (PTH), an agent of bone remodeling. A recent study suggests that HMGB1 acts as a chemotactic agent to osteoclasts and osteoblasts during endochondral ossification. To explore the potential impact of HMGB1 in the bone microenvironment and its mechanism of release by osseous cells, we characterized the effects of recombinant protein (rHMGB1) on multiple murine bone cell preparations that together exhibit the various cell phenotypes present in bone. We also inquired whether apoptotic bone cells release HMGB1. rHMGB1 enhanced the RANKL/OPG steady state mRNA ratio and dramatically augmented the release of tumor necrosis factor‐alpha (TNFα) and interleukin‐6 (IL6) in osteoblastogenic bone marrow stromal cell (BMSC) cultures but not in the calvarial‐derived MC3T3‐E1 cells. Interestingly, rH

Who reads HMGB1 is a bone‐active cytokine?

Author

Jieping Yang; Rita Shah; Alexander G. Robling; Evan Templeton; Huan Yang; Kevin J. Tracey; Joseph P. Bidwell

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)