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This study investigates the relationship between furosemide prescription and serum concentrations of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD). In a cohort of 2342 CKD patients, those prescribed furosemide, particularly at doses over 120 mg, exhibited significantly higher serum levels of various uremic toxins compared to non-prescribed patients. The findings suggest that furosemide may contribute to the accumulation of PBUTs due to competition for renal excretion path

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tttkh

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