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Op0172 Effect Of Weight Loss And Liraglutide On Serum Urate Levels Among Obese Knee Osteoarthritis Patients: Secondary Analysis Of A Randomised Controlled Trial by K. Zobbe; S. M. Nielsen; R. Christensen; A. Overgaard; H. Gudbergsen; M. Henriksen; H. Bliddal; L. Dreyer; L. Stamp; F. Krag Knop; L. E. Kristensen is a Medicine article available to read on EtoBox.
What is Op0172 Effect Of Weight Loss And Liraglutide On Serum Urate Levels Among Obese Knee Osteoarthritis Patients: Secondary Analysis Of A Randomised Controlled Trial about?
## Background: There is a strong association between gout and obesity. Lowering urate is the cornerstone of gout management [1] and urate levels correlate strongly with central obesity. Previous studies suggest that weight loss has a positive effect on serum urate, however, the studies are sparse and small [2]. ## Objectives: To assess the impact of an initial low-calorie diet-induced weight loss and subsequent randomisation to the body weight-lowering drug liraglutide (a glucagon-like peptide 1 receptor agonist) or placebo on serum urate levels. ## Methods: In the LOSE-IT trial (NCT02905864), a randomised, double-blinded, placebo-controlled, parallel group, single-centre trial [3], 156 obese individuals with knee osteoarthritis, but without gout, were offered an initial 8-week intensive diet intervention (week -8 to 0) on Cambridge Weight Plan (800-1000 kcal/day) followed by a weight loss maintenance period in which participants were randomised to either liraglutide 3 mg/day or placebo for 52 weeks. We conducted a secondary analysis of blood samples collected at week -8, 0 and 52. The primary outcome measure was change in serum urate. We used paired t-test for the change from week
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- Author
- K. Zobbe; S. M. Nielsen; R. Christensen; A. Overgaard; H. Gudbergsen; M. Henriksen; H. Bliddal; L. Dreyer; L. Stamp; F. Krag Knop; L. E. Kristensen
- Publisher
- BMJ
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)